Absolutely. That's my natural position and I've been typing hours per day for 20 years with no signs of stress injuries at all.
A good way to describe it is that the home keys are not asdf jkl; but rather more like qwdc mkp[ . I don't have any real fixed home position though, my wrists always "float" over the keyboard. Particularly the right wrist spends more time near the brackets and slashes for programming.
