Although this is subjective, the kinesis advantage keyboard has really helped me better deal with my RSI; it has clusters of keys under each thumb and is fully programmable so I am able to move problem keys around (for me pinky keys are quite uncomfortable).
For me shift, space, backspace, tab, win, ctrl, alt, esc and enter are all thumb operations.
However I wouldn't go as far as saying it has solved my RSI, but it is definitely part of the solution that allows me to program 40+ hours a week (more like 50-60, 40 hour week professional + hobby programming).
FWIW the other parts include regular exercise, alternating mouse hands and using a trackball on my 'off hand', and a keyboard-heavy system (vim, dwm, etc.).
For me shift, space, backspace, tab, win, ctrl, alt, esc and enter are all thumb operations.
However I wouldn't go as far as saying it has solved my RSI, but it is definitely part of the solution that allows me to program 40+ hours a week (more like 50-60, 40 hour week professional + hobby programming).
FWIW the other parts include regular exercise, alternating mouse hands and using a trackball on my 'off hand', and a keyboard-heavy system (vim, dwm, etc.).