I'm not saying it is more difficult. I'm saying that it's not any less complex by the time you put everything you need together. In other words, it's a wash, so I just use Django instead. Fewer dependencies to install, fewer helper functions to write (because many of them already exist), and more components that are designed to work together.

And then there are other things such as having all of your URLs specified on one place vs. as decorators with your controllers. But that's just my personal preference.