Besides the straight-up superiority of the 22 degree angle, the monitor setup that works best varies greatly from one person to the next. It’s interesting how big the difference is. My favorite so far has been two 32” 4K IPS panels, flat!, plus a 15” laptop AND a tablet sidecar display occasionally. I appreciate the difference more clearly after I had a colleage who saw much of the same patterns in code and software architecture as I did – very similar end result of thought processes - but they were happy as a clam with just a 13” laptop and nothing else. It was so obvious that their mind just works differently from mine. My setup only served as a distraction to them and theirs to me.