I do care about ergonomics, and everyone comments that I hold a mouse a bit Strangely (kind of at an angle), but I just can't get used to a trackball :(
I've tried a few things, the first something like 20 years ago. More recently I stuck with it for a full week, but it still felt really awkward, and like I just couldn't be as accurate as with a mouse.
If you've any pointers (hur hur), they'd be much appreciated!
Critical to the experience was disabling the "Enhance Pointer Precision" setting on Windows, which ironically felt like it does the exact opposite of what it says.
I probably wouldn't use it for, say, competitive FPS games but for regular workflow stuff it's just great.
I switched four months ago and my small remaining wrist issues are completely gone.