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Given that software is composed of a hierarchy of dependencies, I would like to see a funding approach that works at the dependency tree level to support an entire tree or sub tree. There is a huge freeloader problem where business don't contribute any support for their core dependencies. I wonder if there is a role for an organization that could act as the interface for corporate support at the dependency tree level. It could offload maintainers (or fund them) to handle certain compliance requirements and provide an official sanctioned entity for purposes of corporate policies. There should be a way to garner support broadly for risk management and specifically for security in the corporate context.


This paper from Africa Health Research Institute shows a 41x reduction in effectiveness of pfizer vaccine for omicron.

https://www.ahri.org/omicron-incompletely-escapes-immunity-i... https://www.ahri.org/wp-content/uploads/2021/12/MEDRXIV-2021...


This preprint also shows reduced antibody neutralization of omicron in comparison to delta (including for double vaccinated + previous infection).

Note the sample sizes for all these studies is small. 12 participants for the AHRI paper and 8 to 20 per group for this one.

https://www.medrxiv.org/content/10.1101/2021.12.07.21267432v...


Sample size doesn't really matter much in this kind of study.


Ideally you'd match it to some population of interest. For my own medical affairs, I don't care what grand-pappy's results are here, I want to know how cousin Tim fairs.


Why not? I’m no statistician, so my basic understanding is you should always prefer bigger sample sizes to ensure statistically significant findings.


This paper doesn't even attempt to measure effectiveness. It measures neutralization titers which is a totally different thing.


See: https://www.news-medical.net/news/20200731/Research-suggests...

In addition to immunity based on T cells, the HIT depends on how individuals are networked. The original 60-70% estimates were based on 100% of people being vulnerable and also a random distribution of individuals interacting. In reality a small fraction of the population will have many interactions and once they become immune those transmission vectors away and the average R number drops. So based on the latest research plus observations of the worst hit places, 20-25% seems plausible.


The Biggest Ideas in the Universe A physics tour de force by Sean Carroll https://www.youtube.com/watch?v=HI09kat_GeI&list=PLrxfgDEc2N...


How about if we insisted you have 1,000,000 USD to buy guns or alcohol?


Alternatively pass regulations to make private companies over a certain size report more.


The parent is giving an example where it is clear cut.


Nothing would stop them from tracking access based on location.


Websites are public. The act of publishing on one is an explicit opt-in.


Would this work with water flows?


Well there's hydropower (gravity) or tidal power (celestial bodies). Otherwise I don't think water can be focused the way wind can.


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