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That is one part, the other part is that you would get more persistent high pressure blocking patterns over Europe due to reordered atmosphere circulation which will lead to more intense droughts. That is what happened this summer.


Current research is that it would get a lot drier than it is currently. Also the AMOC collapse process would play out over many decades (~50-100 years) it will not be a sudden event.


SSRIs have much more clinical evidence of efficacy for addressing anxiety disorders vs a placebo than depression. The effect size is ~0.7 vs 0.2 in meta studies.


Totally agree, they really shouldn't be called antidepressants at all. Important to add tho that for many with depression they have comorbid anxiety and often the anxiety is harder to tolerate than depression, so removal of anxiety symptoms can be hugely beneficial.

Also, IME they are dosed completely wrong. So many people seem to be on very low doses, which has no improvement on placebo in the studies I've read.

Whereas, higher doses are _hugely_ better than placebo, especially for anxiety.

What's worse is a lot/most studies on SSRIs in general often don't adjust for dose. Which seems like an enormous oversight to me.


A good book on this is Mind Fixers: Psychiatry's Troubled Search for the Biology of Mental Illness. Describing the history of how many of these classes of drugs came about is pretty eye opening, I would say the book is pretty nuanced in its conclusions.

https://www.goodreads.com/en/book/show/40180010-mind-fixers

The title is a play on the Pulitzer prize winning article from the 80's.

https://web.archive.org/web/20041125092022/http://www.byline...


We are certainly seeing higher monetary velocity in certain sectors. That usually follows from real economic expansion but could also be due in part to inflation.


Extensible trait support seems like another big one if the ecosystem is going to significantly grow. Not having clearly defined traits in the language made larger projects composing many libraries in Julia difficult.


You forgot to add that he was in a relationship and later engaged to the chief of staff at Anthropic while raising and running his fund, but I’m sure he had no access to material non-public information.


And the margin call literally happened during the wedding


What polls are you seeing where public opposition is starting to break? All the polling seems to be heading strongly in a negative direction. The Texas governor even had to accept political reality and seem like he was recognizing public anger. At a protest in Salem OR a guy just the other day showed up with a literal guillotine and the CEO had to leave the meeting. People making rational arguments don’t recognize this has become a deeply emotional argument and the emotions right now are broadly not good. It feels similar to the Tea Party movement after 2008.


I'm not seeing polling break, just opinion writing. You're kind of making my case for me when you talk about people showing up to protests with guillotines.


I don’t know if I would trust opinion writing to be predictive of a growing reactive populist movement. I would caution people being dismissive of how angry people are, data centers are just a political focusing mechanism. It will get worse of course if all of this ends with an economic shock.


I agree that a lot of data center advocacy is just incoherent polarization and populism, as evidenced by the guillotines.


Reuters/Ipsos did some polling on general sentiment about data center construction nationwide last month. “Building data centers at a rapid pace across the US is mainly a good thing” only 33% support, which is a +15% change from local community buildout but hardly a majority.

https://www.reuters.com/world/us/americans-wary-ai-driven-da...


It’s largely associated methane co-produced from oil production in the Permian. The economics of co-production means that the gas is often the cheapest in the nation and can have negative prices during large oil production swings. I believe it went nearly -$10 MMBtu this year at one point.


That would suggest if no-one purchased it, it would just be flared off. Does the negative price come about because of pathological financial conditions, or is it the case that the producers are financially penalised for flaring?


It acts as a negative feedback signal for producers because there is limited physical pipeline capacity. I think there are some financial incentives to reduce flaring for the LNG export market, but only a small amount of gas was flared in that region (less than 5%).


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