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This is all well outside my area of expertise, but my impression is that Michael Levin's work with bioelectricity is on the cusp of #6 Somatic limb regeneration.

SMEs please correct the record if I'm mistaken.


Unfamiliar with Levin’s work, but:

There’s also this study [0] I read recently, along a different path of using known growth factors and proteins to kick off regeneration.

[0] https://www.nature.com/articles/s41467-026-72066-8


ECM (Extracellular Matrix) has been studied for similar properties:

https://www.biorxiv.org/content/10.64898/2026.08.05.742898v1...

"Extracellular matrix particle treatment induces digit regeneration in soft-tissue preserved amputation (SPA) model of adult mice"


Everyone interested in biology and intelligence should look up Michaels work, it is amazing because he's ignored a lot of assumptions that are held by the community and come up with new and interesting tests.

Also his work on algorithmic intelligence in cells and the mathematical foundation of intelligence will change many fields, including AI, if it can be empirically tested.


So glad to see this preserved.

It was sad to discover zombocom finally died an undignified death earlier this year.


Zombo still works

The domain was purchased and redesigned. It still exists but lost something ineffable in the process.

Along with all the other wonderfully, nonsense, single-purpose sites we've lost over the years. Some documented here: https://theuselessweb.com/sites-we-lost/

We're evolutionarily programmed to stop everything and focus on anything that elicits fear in our environment. Enormous amounts of money has been invested to design algorithms that capture our attention with fear because they need your attention to sell advertising. Everything's optimized to make you enraged and afraid because it works. They're really good at it too.

I know they got my number. I've had to delete every social media site I used to be engaged in (I suppose except this one) for the sake of my mental health.


I'm on my last Samsung for this reason. Just way too much bloatware, need to agree to a new privacy policy once a week, and every time it updates I find a few new apps on my phone I didn't want.

Gonna hold out for the Motorola/Graphene phone though. One of the models is supposed to be a flagship foldable.


imo just get a pixel. unlockable bootloader and almost guaranteed support from pretty much every major privacy-related android fork. and many of them are building support for the titan chip if they dont have it already


I also have a Samsung phone besides a Pixel with GrapheneOS and I just ripped out Gemini, most of Bixby, etc. using UAD-ng. It's very clean now, but I still have all the customizability of OneUI, Good Lock, etc.


Unless you really have a large ethical problem with paying for any google product, I'd just recommend to get one of the previous-gen pixel devices. They are a lot cheaper than the Motorola smartphone coming out.


Although the author turned out to be a fairly despicable person, Prime Obsession is an absolutely wonderful book on this subject.


This is one of the few places I ever engage on the internet, but I think it may be time for HN to be read-only, too.

This didn't seem especially controversial of a comment, and even here there's no end of the rotten attitudes for no good reason


What you call rotten attitudes seemed like fairly thoughtfully doing the research you left out of an opaque and off-topic character determination.

Read-only or read never is looking wiser than it did a few years ago.


I despise vague and quasi-anonymous attacks like this. "Trust me, online person, I, a random netizen, have made a moral judgment and you should have complete faith in it."

Google summarizes the controversy thus, from Wikipedia:

"John Derbyshire is an American journalist and political commentator. He was one of the last paleoconservatives at the National Review, until he was fired in 2012 for writing an article for Taki's Magazine that was widely described as racist. Since 2012 he has written for white nationalist website VDARE. Wikipedia


Would you prefer OC was more specific, ie “the author turned out to be a racist”, or do you have an issue with calling someone like this despicable?


Obviously, I would prefer OC was more specific. I said as much.


Genuine question: are you on the spectrum? I find this reaction strange


Wait... so you are perfectly OK with hating someone on the basis of some random online poster telling you that you should, with no explanation?

Wow.


I don’t automatically hate someone because someone calls them despicable


I always read that word as though it were being pronounced by Daffy Duck; "you're dethpikable!".


Is it not obvious? Replace “fairly despicable” with “white nationalist” instead of whatever anyone might imagine could make a mathematician despicable?


Why does this shorthand upset you?


A shorthand is generally unambiguous in context; this was not.


Why does it matter to you so much that OC is unambiguous?


It was off-topic already. You driving it further is obsessive and ill-intended.


Because I'm not on-board with every moral failing that is called “despicable” by someone being disqualifying or even relevant.


I am not upset. It is obviously obstusely, impenetrably vague. What is your problem?


My earliest introduction to locusts was as a biblical plague. These Sunday school lessons did not include pictures. I always imagined some twisted diminutive demonic swarm of insects, and was disappointed to finally discover they were just grasshoppers.


> I always imagined some twisted diminutive demonic swarm of insects

Behavioral ecologist Stephen Simpson has proposed the cannibalistic forced march hypothesis[36], that is, the forward motion of a locust swarm is essentially sustained by each individual’s imperative to avoid being eaten by the locust behind it: 1) Align their body axis with neighbors (parallel) to minimize the chances of a side-on attack and present their narrowest possible profile to the individual behind. 2) March forward to bite and feed on the abdomen of the locust immediately ahead.

A billion crazed insects marching through eating all your crops while cannibalizing each other does seem relatively twisted and demonic.


Also, there’s the stimulus causing nymphs to not be solitarious slow green grass-nibbles, but instead transform into armored, black and yellow, upright marching machines that mature into stronger-winged battle bugs. With soft tasty abdomens exposed to the soldier behind them…


Woah up until now I was thinking locusts were a different but related species, but indeed they are the exact same species as grasshopper, just with a different end-product of metamorphosis. And the trigger is just contact with other grasshopper/locusts.

https://www.youtube.com/watch?v=uURqcI08IC4


I have been in a locust plague once. It does feel very weird. Yes they are grasshoppers but you might be underestimating just how many there are. Plus they don't look normal, they actually change appearance when they're in a plague.

One small detail I remember was when the sun was just behind a building, you could see this glow around the building which was the sun reflecting off all the locusts that were flying around it


I don't know if it qualifies as a plague of locusts because I do not know where the line is drawn, but the grasshopers were thick one year at my parents' house (which is itself surrounded by flatness and farm fields).

They were ravenous things. That ate everything. Not just "food," either, though eating a snack outside was certainly impossible and merely being outside was treacherous.

These bugs ate things like window screens, cut slivers from a vinyl swimming pool, and dined upon the siding of the house. It was really fuckin' weird even being inside of the house, since the noise of it being pelted by grasshoppers (locusts?) never really slowed down.

That was probably 25 years ago. It never happened again.


One locust is an interesting bug. Billions of locusts are an apocalyptic nightmare.


Put them under a microscope at 10-40 times magnification and you've got your demons. Claws and hooks and fang-like attachments everywhere, faceted eyes, crusty exterior. The western image of demons was partly derived from insectoid creatures by painters like Hieronymus Bosch so it makes sense for insects to look demonic.


I'm desperately awaiting the perfect eink device for this.

I've got a great writing setup on Obsidian that really works for me, a royal kludge mechanical keyboard...just waiting on the next gen of eink

The Boox One Note Max was sooo close, but they almost immediately discontinued the product and probably won't be supporting it long.

Suggestions are welcome


My wife bought one of these: https://getfreewrite.com/products/freewrite-traveler

Reviews are wildly polarised. * Some folks find it to be the best thing ever [long battery life, the new patch makes the eink surprisingly fastly responsive, decent keyboard, no distractions] * While others find it terrible [it's still eink, that's a lot of money for a device that doesn't actually do much]

You can find a selection of alternatives, and homebrewed options, here: https://www.writerdeck.org/


That looks really cool, but that price point. I could get a Steam Deck + travel keyboard and still come out ahead.

Is that the true price for a low volume, niche product? Eink monopoly continues to make the world worse?

Looked it up, and the original One Laptop per Child came in around $200


I was gifted a Traveler several years ago. It is overpriced and bound to the vendor data service for any connected functionality. You can read and write off of it via USB, but it doesn't actually use a true filesystem for your text files, it writes them into the main app's sqlite DB, which in the past has had data loss issues.

My version uses ancient releases of Node and React for the UI for some horrible reason, and it is painfully slow.

I've rooted mine and have it as a project to look at the new OS and decide what to do with it, but if I had the cash I'd look elsewhere.


> bound to the vendor data service for any connected functionality.

This is why I don't own a Freewrite. It should be such a simple device, but they found a way to make it complicated and lock it into their proprietary ecosystem. No thanks.


It would be a better device if I could install cfw and make it somewhat more versatile. But I haven't found anyone doing that, and haven't even found enough specs online to get started.


I ought to do a write up, but If you open it up the UART pads are available to get a U-Boot console. U-boot is in HAB mode, with a custom signed debian buster kernel. This was my first time dealing wit u-boot, but it was otherwise pretty open and was able to write to ENV and FS from the u-boot console, which let me stop the Freewrite app from starting, boot into root shell, turn on SSH, etc. So you can get into userspace and replace the UI and whole app. When I dropped this project I had it booting shell onto the e-ink, with a command to drop back into the Freewrite app if I wanted.

Then they released the new app, which looked like it was also just in userspace (not a kernel or fw update) so I wanted to start over with the update, but never got back to it.


Looks great but the price is pretty insane, and really the eink should be a lot bigger. So much wasted space on the bezels.


For some reason writerdecks almost all insist on having tiny little screens.


I think it's more a supply chain issue. There aren't any very stretched rectangular eInk panels from what I've been seeing. I've seen some for price tags but I mean nothing like 8-10 inches or so.

And they're such a niche phenomenon that they have to do with the scraps left by other industries like ereaders.


That homebrew page is pure gold. Thank you for the suggestion!


I use the Onyx Boox Palma for a portable eink drafting setup. It's worked pretty well. I wrote about it here: https://liza.io/portable-writing-setup-with-onyx-boox-palma/


That's very similar to the setup I'm working on, including the stand. Thanks for sharing!

One of the appealing features on the Note Max was the screen size (13.3"). How do you find working on such a small screen?


For me the small screen is fine as long as I can maintain the mindset of this being a _drafting_ tool, not an editing or structuring tool. I generally don't need to see more than a couple of sentences at a time, and my drafting process is almost stream-of-consciousness as I just focus on getting the words out. If I needed to navigate more to edit or regularly reference prior sections, the small screen would be a hindrance.


> The keyboad

Perhaps you should have chosen a better one?!


I chose the keyboard I wanted :)


It was a joke on the typo.


Hahaha I missed that completely, sorry.

...Now I kind of don't want to fix it :D


make the "r" a link to this discussion thread. btw you made the typo twice :-)


Great idea, done.

I fixed the second one normally because that's just embarrassing. I guess at least we know it was really written by a human? ;)


My dream device is the "Solar A5 e-ink computer" - It's A5-sized laptop, so it fits in a leather zipped case for journals. If you're familiar with HP Journadas / Sony Vaios from early 2000s, that's roughly the form factor. There's a solar panel on the back of the screen / outside of the enclosure. The screen is e-ink, and the operating system is Linux Mint Debian Edition. For console mode, a good "writing station" applications are "mc" (Midnight Commander) and "ranger" - simple GUI for editing text in folders, like a blog/knowledge base.

Some challenges I've experienced: (1) Can't find A5-sized e-ink screens that accept HDMI as an input, (2) It would be cool to use a common Android phone, since there are many around. RaspberryPI is an option. Honestly, would love the simplest portable device that runs Debian Stable on a battery, (3) I have NOT been able to find small, A5-sized keyboards. Most small keyboards are cheap plastic bluetooth junk.

If anyone would like to seriously rally around this, let's talk'bout it. My vision for this laptop has always been "10:00 AM Austin Texas, sitting at a patio bar in direct sun, journalling/coding/writing". I have not been able to find any computer device that satisfies that situation, so there is obviously a market niche.


I use a Bigme Hibreak Pro eink phone, nix-on-droid/ssh to home server over tailscale, and a foldable keyboard, to have my coding setup with me and not be tied to where I can carry a laptop.

For foldable keyboards, if they are flimsy or stable matters.


I use a pine note + a bluetooth keyboard + SSH / VPN to make that work for me. It's acceptable. I would like "a laptop", but it's fine.


The Pomera line of devices from the Japanese company "King Jim" (yeah, I don't know) are really nice from a features point of view: limited enough to stay out of your way when you're writing, functional enough to enable the basic workflows you'd expect e.g. basic file management, SD card/USB transfers (something that many/most/all Western boutique writing devices like the Freewrite somehow didn't support well or at all last time I checked). Somewhere I have a funky e-ink Pomera thing with a folding keyboard that I did a lot of writing on, and later I bought a DM250, which is not e-ink but works pretty much the same, and now has a US version. I recommend it.


The US version (the DM250US) is now $549, alas. I was looking at these briefly, but can’t justify the expense — might as well get a MacBook Neo if I were in the market.


Yeah I think that's substantially more than I paid for my JP market version.

I will say it is a really nice device, probably the all-around best of the dedicated writing devices I've owned and/or researched over the years. But on a typical value scale, it's not worth that.


Onyx iterates on its BOOX tablets fairly rapidly, but tends to continuously offer something in various size classifications. You'll find 13.3" tablets typically named as "Max" something or other.

I do see the Note Max as presently available, FWIW: <https://shop.boox.com/products/notemax>

I've had a previous iteration of their 13.3" tablet, the Max Lumi. Slightly lower resolution, and has a frontlight. It is a very nice display, though with an Android OS which I see as a net negative.

I'd really like an e-ink display option for the Framework 12" or 13" laptop.


If your up for waiting and the usual crowd funding risks there's https://www.kickstarter.com/projects/zerowriter/zerowriter-f...

I backed it myself.


Ideally, somebody like Modos would create a replacement e-ink display for the Framework.


If you want something you can use today with a Kindle or other e-reader I made an app for this https://solarwriter.msol.io



I understood that the move to non-replaceable batteries was at least partially driven by water resistance

*Edit. Not sure why people are downvoting. I didn't make a positive declaration. HN didn't used to be this way for completely milquetoast comments.


It probably makes things easier, but its unlikely that the industry that found a way to make foldables waterproof couldn't figure out a way to put rubber gaskets on battery covers. And in fact, they did, there were several devices introduced in the transition period that had both features.


Rubber gaskets wear out. Best practice is to replace them every time you open the cover. We can put them in, but the replacement battery better come with the gasket because you can't safely replace the battery without a new gasket.


Galaxy S5 was IP67-rated (1 metre depth, 30 minutes) and had a user-replaceable back cover / battery

Also a notification LED, OLED screen, bezels to pick the device up by, headphone jack, unlockable, a continuous light sensor... peak smartphone, save perhaps for the meager 200 Hz accelerometer refresh rate (modern phones have 500 Hz usually, I have no idea what for but I personally love toying with FFT plots)


If the headphone port flap was perfectly sealed….


*charge port flap


Waterproof phones all still have charging ports and no flaps. Not sure how but that seems to be solved. Maybe that one part's connectors are encased in glue?


Yes and don't forget consumer preferences. This is Hacker News where they are still clamoring for a "small smartphone" because everything else is too big. Shocker, small phones don't sell. Neither do bulky ones when compared to sleek iPhones.


Haven't modern smartphones had non-replaceable batteries long before they had any kind of water resistance ratings?


Not sure if I should be repeating the same answer below each instance of the question but here goes: See the Samsung Galaxy S5 for example as having a good waterproofing rating and user-replaceable battery


Anything except full support of the EU during European hours gets downvoted


Every post about the EU here gets absolutely flooded by negative comments of people who tell me that whatever the EU proposed won't work, governments shouldn't do these things, the proposed legislation is ineffective, it doesn't go far enough, they're just trying to extract money from our successful American companies, and so on and so forth. It's just a neverending diarrhoea of anti-government anti-European underbelly sentiment.


That sounds like seeing a pattern where there is none (apophenia). Do you have examples of posts that wouldn't be downvoted outside of times where Europe/Africa is awake, or that weren't only because it was posted outside of said hours?


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